RESUMEN
BACKGROUND: Sinonasal neoplasms, whether benign and malignant, pose a significant challenge to clinicians and represent a model area for multidisciplinary collaboration in order to optimize patient care. The International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors (ICSNT) aims to summarize the best available evidence and presents 48 thematic and histopathology-based topics spanning the field. METHODS: In accordance with prior International Consensus Statement on Allergy and Rhinology documents, ICSNT assigned each topic as an Evidence-Based Review with Recommendations, Evidence-Based Review, and Literature Review based on the level of evidence. An international group of multidisciplinary author teams were assembled for the topic reviews using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses format, and completed sections underwent a thorough and iterative consensus-building process. The final document underwent rigorous synthesis and review prior to publication. RESULTS: The ICSNT document consists of four major sections: general principles, benign neoplasms and lesions, malignant neoplasms, and quality of life and surveillance. It covers 48 conceptual and/or histopathology-based topics relevant to sinonasal neoplasms and masses. Topics with a high level of evidence provided specific recommendations, while other areas summarized the current state of evidence. A final section highlights research opportunities and future directions, contributing to advancing knowledge and community intervention. CONCLUSION: As an embodiment of the multidisciplinary and collaborative model of care in sinonasal neoplasms and masses, ICSNT was designed as a comprehensive, international, and multidisciplinary collaborative endeavor. Its primary objective is to summarize the existing evidence in the field of sinonasal neoplasms and masses.
Asunto(s)
Neoplasias de Cabeza y Cuello , Hipersensibilidad , Neoplasias de los Senos Paranasales , Humanos , Calidad de Vida , Neoplasias de los Senos Paranasales/terapia , Neoplasias de los Senos Paranasales/patologíaRESUMEN
ABSTRACT INTRODUCTION: Bismuth subgallate is a salt derived from heavy metal. The aim of this study was to evaluate the effect of this salt on some phases of healing. OBJECTIVES: To assess the effect of subgallate on mucosa and to evaluate the association between the use of bismuth subgallate and neogenesis of vessels in oral mucosal wounds. METHODS: This was a prospective and experimental study. This study used sixty rats, which were divided into control and experimental groups. The animals were submitted to a surgical procedure, which caused oral mucosal injury. A saline solution was applied on the wound of the control group, and in the experimental group, a solution of bismuth subgallate was administrated. RESULTS: The experimental group showed greater inflammatory reaction with increasing monomorphic proliferation. There was increased vessel proliferation in the control group. CONCLUSION: Bismuth subgallate had a negative influence on the healing process, delaying the rate of new vessel formation and optimal wound healing.
RESUMO INTRODUÇÃO: O subgalato de bismuto é um sal derivado de metal pesado. A ideia desta pesquisa é avaliar sua interferência em alguma das fases da cicatrização. OBJETIVO: Delinear a ação do subgalato em mucosas. Avaliar a relação entre a utilização do subgalato de bismuto e a neoformação de vasos nas feridas em mucosa oral, para evidenciar o possível benefício resultante do seu uso. MÉTODO: Estudo experimental, prospectivo. Utilizou-se sessenta ratos, que foram divididos igualmente em grupo controle e experimento. Foram submetidos a um procedimento cirúrgico onde foi feito uma lesão na mucosa oral dos animais, após, uma solução de soro fisiológico foi aplicada sobre a lesão do grupo controle e sobre a ferida do grupo experimento foi aplicada uma solução de subgalato de bismuto. RESULTADOS: o grupo experimento apresentou maior reação inflamatória com crescente proliferação monomórfica. Vasos: houve maior proliferação no grupo controle. CONCLUSÕES: concluiu-se que o subgalato de bismuto teve uma ação negativa no processo de cicatrização, atrasando a velocidade de formação dos neovasos e a cicatrização ideal da ferida operatória.
Asunto(s)
Animales , Humanos , Masculino , Ratas , Inductores de la Angiogénesis/uso terapéutico , Ácido Gálico/análogos & derivados , Compuestos Organometálicos/uso terapéutico , Cicatrización de Heridas/efectos de los fármacos , Modelos Animales de Enfermedad , Ácido Gálico/uso terapéutico , Mucosa Bucal/irrigación sanguínea , Mucosa Bucal/cirugía , Estudios Prospectivos , TonsilectomíaRESUMEN
INTRODUCTION: Bismuth subgallate is a salt derived from heavy metal. The aim of this study was to evaluate the effect of this salt on some phases of healing. OBJECTIVES: To assess the effect of subgallate on mucosa and to evaluate the association between the use of bismuth subgallate and neogenesis of vessels in oral mucosal wounds. METHODS: This was a prospective and experimental study. This study used sixty rats, which were divided into control and experimental groups. The animals were submitted to a surgical procedure, which caused oral mucosal injury. A saline solution was applied on the wound of the control group, and in the experimental group, a solution of bismuth subgallate was administrated. RESULTS: The experimental group showed greater inflammatory reaction with increasing monomorphic proliferation. There was increased vessel proliferation in the control group. CONCLUSION: Bismuth subgallate had a negative influence on the healing process, delaying the rate of new vessel formation and optimal wound healing.
